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Briacavatolides D–F, New Briaranes from the Taiwanese Octocoral Briareum excavatum

Molecular Diversity Preservation International
Publication Date
  • <Em>Briareum Excavatum</Em>
  • Briarane-Type Diterpenoid
  • Cytotoxicity
  • Anti-Hcmv


In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D–F (1–3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–3 and their cytotoxicity against selected cancer cell lines were evaluated.

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