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Studies on Fatty Acids of Rat Ascites Hepatoma AH130 Transplanted into Essential Fatty Acid Deficient Rat

Authors
Publisher
千葉医学会
Publication Date
Keywords
  • 腹水肝癌細胞Ah130
  • 必須脂肪酸欠乏ラット
  • 20:3(N-9)
  • 原著
  • Ndc:490
Disciplines
  • Medicine

Abstract

AH 130 ascites hepatoma was transplanted into the Donryu rat on a fat-free diet and the distribution of fatty acids in the AH 130 tumor cells, the host liver and the serum were analyzed to clarify the mechanism of lipid metabolism in the malignant tumor cells. In the AH 130 tumor cells, the host liver and the serum, increment of content of 18:1 (n-9) and decrement of content of 18:2 (n-6) with appearance of 20:3 (n-9) and disappearance of 20:3 (n-6) were found. However, content of 20:4 (n-6) which was decreased in the host liver and the serum was unchanged in the AH 130 tumor cells. These results suggest that a specific mechanism for lipid metabolism exists in the AH 130 tumor cells although the composition of fatty acids in the AH 130 tumor cells was influenced by the change of those in the host under the condition of essential fatty acid deficiency.

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