Affordable Access

Publisher Website

HMGB-1-Chapter 39

Authors
Publisher
Elsevier Ltd
Identifiers
DOI: 10.1016/b978-012689663-3/50043-0
Disciplines
  • Biology
  • Medicine

Abstract

Publisher Summary The identification of tumor necrosis factor (TNF) as an early mediator of inflammation led to clinical therapies, which have improved the clinical course of many patients suffering from chronic inflammatory disease. Anti-TNF strategies have met with little success in diseases of acute systemic inflammation such as sepsis. It is hoped that the discovery and characterization of new cytokines, and pathological mechanisms will be important to the development of future therapies for inflammation. HMGB-1, first identified as a nuclear chromosomal protein, is now known as a proinflammatory cytokine that mediates delayed lethality in systemic inflammation. The discovery of HMGB-1 as a monocyte-derived, late-acting cytokine mediator of endotoxin lethality has initiated a new field of investigation for the development of experimental therapeutics. The downstream or “late” action of HMGB-1 is a marked departure from the early activities of TNF, and other classical proinflammatory cytokines, and has significant implications for understanding, and manipulating innate immune responses. Emerging data also suggest that therapeutics that inhibit HMGB-1 activity that are effective in preventing death in murine sepsis. The insights gained from these and other studies of HMGB-1 may lead to the development of new compounds which provide a wider therapeutic window for treatment of endotoxemia, sepsis, and septic shock.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

[HMGB1].

on Nihon rinsho. Japanese journal... August 2005

[HMGB1].

on Nihon rinsho. Japanese journal... July 2010

HMGB1 in sepsis.

on Scandinavian journal of infect... 2003

HMGB1 in health and disease

on Molecular Aspects of Medicine
More articles like this..