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Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Identifiers
DOI: 10.1016/j.bmcl.2014.05.083
Keywords
  • Xylarianaphthol-1
  • Dinaphthofuran
  • Marine Natural Product
  • Structure Elucidation
  • Total Synthesis
  • P21 Promoter Activator
Disciplines
  • Biology
  • Chemistry

Abstract

Abstract Xylarianaphthol-1, a novel dinaphthofuran derivative, was isolated from a marine sponge-derived fungus of order Xylariales on the guidance of a bioassay using the transfected human osteosarcoma MG63 cells (MG63luc+). The chemical structure of xylarianaphthol-1 was determined from the 1H and 13C NMR analysis and was further confirmed by the total synthesis. Xylarianaphthol-1 activated p21 promoter stably transfected in MG63 cells dose-dependently. Expression of p21 protein in the wild-type MG63 cells was also increased by xylarianaphthol-1 treatment.

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