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High-dose versus low-dose nebulized albuterol in acute asthmatic attack: a randomized double-blind clinical trial

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S1 Available online Critical Care Volume 9 Suppl 1, 2005 25th International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium, 21–25 March 2005 Published online: 7 March 2005 These abstracts are online at © 2005 BioMed Central Ltd P1 Severe community-acquired pneumonia in the intensive care unit C Costa, I Gouveia, P Cunha, R Milheiro, A Bártolo, C Gonçalves, A Carvalho, T Cardoso, S Martins, J Magalhães HSO, Guimarães, Portugal Critical Care 2005, 9(Suppl 1):P1 (DOI 10.1186/cc3064) Introduction Community-acquired pneumonia remains a common condition worldwide. It is associated with significant morbidity and mortality. The aim of this study was to evaluate conditions that could predict a poor outcome. Design Retrospective analyse of 69 patients admitted to the ICU from 1996 to 2003. Demographic data included age, sex and medical history. Etiologic agents, multiorgan dysfunction, noso- comial infections, SAPS II and PORT scores were recorded for each patient. For statistical analysis we used a t test, chi-square test and Mann–Whitney U test on SPSS®. A value of P less than 0.05 was considered significant. Results Forty-seven patients were male and 22 patients were female. Mean age was 52 years. Sixty-seven percent had serious pre-morbid conditions including pulmonary disease (34.8%), cardiac problems (36.2%), diabetes (13%) and chronic liver disease (5.8%); 40.6% were smokers, drug abusers or alcohol dependents. Sixty- eight patients required invasive mechanical ventilation. The average length of ventilation was 13.5 days, median 8 days. The mean SAPS II score was 40.14 and the mean PORT score was 141. The mortality rate was 27.5% (SAPS II estimated mortality, 35%). Complications reported were ARDS (40.6%), septic shock (34.8%), acute renal failure (2.9%), cardiac arrest (8.7%) and nosocomial infeccions (46.4%). Mortality rates were higher for previous hepatic (75%) and metabolic (33%) diseases.

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