The measurements of single W, Z boson production in association with jets probes QCD in a multi-scale environment. In this paper, we summarize the latest measurements of W+jet and Z+jet production and their ratio, extending to high jet multiplicities over a large set of kinematic distributions for proton-proton collisions at a center of mass energy of 7 TeV data at the LHC. The results are compared to the latest theoretical predictions of modern Monte Carlo generators. In addition, the measurement of production of vector bosons in association with heavy flavours allows to study c and b-quark parton distribution functions (PDFs) and gluon splitting effects. Also the corresponding measurements of W + c and Z + b(b) are reported and compared to predictions based on various PDFs in four and five-flavour schemes.