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Glucose regulates pancreatic preprosomatostatin I expression

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
465
Identifiers
DOI: 10.1016/s0014-5793(99)01723-8
Keywords
  • Somatostatin
  • Mrna Slot-Blot Quantitation Technique
  • Rainbow Trout Model System

Abstract

Abstract Rainbow trout were used as a model system to evaluate the role of glucose in regulating the expression of preprosomatostatin I. Glucose increased pancreatic levels of preprosomatostatin I mRNA in vivo, in concert with elevated plasma somatostatin levels, and in vitro. Glucose-stimulated expression of preprosomatostatin I mRNA required the uptake, phosphorylation, and subsequent metabolism of the sugar in pancreatic islets. These results suggest that glucose modulates both the production and release of somatostatin.

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