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Mycobacterial Infections and the Inflammatory Seesaw

Authors
Journal
Cell Host & Microbe
1931-3128
Publisher
Elsevier
Publication Date
Volume
7
Issue
3
Identifiers
DOI: 10.1016/j.chom.2010.03.003
Disciplines
  • Biology

Abstract

Eicosanoids can have either proinflammatory effects or anti-inflammatory effects. Tobin and colleagues use a forward genetic screen in zebrafish to identify a key eicosanoid enzyme, leukotriene A 4 hydrolase (LTA 4H), that controls susceptibility to mycobacterial infection. They also demonstrate that polymorphisms in LTA 4H are associated with susceptibility to mycobacteria in humans.

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