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Whole Body Clearance of Norepinephrine. THE SIGNIFICANCE OF ARTERIAL SAMPLING AND OF SURGICAL STRESS

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Abstract

The whole body clearance of norepinephrine (NE) was measured in seven patients pre- and postoperatively. L[3H]NE was infused intravenously for 90 min and steady-state concentrations of L[3H]NE were measured at 75 and 90 min in both arterial and peripheral venous blood. Preoperatively, in the resting supine position, the clearance values based on arterial and venous sampling averaged 1.4 and 2.5 liter/min, respectively (P < 0.02). The difference in clearance values was due to a peripheral uptake of NE averaging 45%.

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