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Presence of tRNA-dependent pathways correlates with high cysteine content in methanogenic Archaea

Authors
Journal
Trends in Genetics
0168-9525
Publisher
Elsevier
Publication Date
Volume
24
Issue
2
Identifiers
DOI: 10.1016/j.tig.2007.11.007

Abstract

Archeal proteomes can be clustered into two groups based on their cysteine content. One group of proteomes displays a low cysteine content (∼0.7% of the entire proteome), whereas the second group contains twice as many cysteines as the first (∼1.3%). All cysteine-rich organisms belong to the methanogenic Archaea, which generates special cysteine clusters associated with primitive metabolic reactions. Our findings suggest that cysteine plays an important role in early forms of life.

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