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The effect of total parenteral nutrition in the rat on a sub-group of enteroendocrine cells

Authors
Journal
Regulatory Peptides
0167-0115
Publisher
Elsevier
Publication Date
Volume
11
Issue
4
Identifiers
DOI: 10.1016/0167-0115(85)90206-x
Keywords
  • Total Parenteral Nutrition
  • Enteroendocrine Cells
  • Cck
  • Gip
  • Neurotensin
  • Somatostatin
  • Enteroglucagon
Disciplines
  • Medicine

Abstract

Abstract The effect of total parenteral nutrition (TPN) in rats on a number of enteroendocrine cells was investigated. The rats were given a continuous intravenous infusion of basal TPN solution for 7 days. Samples from duodenum, jejunum and ileum were collected, immunostained and the immunoreactive cells quantified using a computerised morphometrics system. The endocrine cells containing somatostatin, cholecystokinin (CCK), gastric inhibitory polypeptide (GIP), neurotensin and enteroglucagon were investigated. The results demonstrated a significant reduction in the number of CCK cells in the duodenum and jejunum. In the ileum the neurotensin-immunoreactive cells were significantly increased in number ( P < 0.02). No change was seen in the number of cells immunostained for somatostatin, GIP or enteroglucagon. These data indicate that short term TPN has a definite effect on the enteroendocrine cell population which may be linked to the side effects of TPN seen in man.

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