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Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis

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BioMed Central
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Abstract

1465-9921-8-17.fm ral ss BioMed CentRespiratory Research Open AcceResearch Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis Mattias Fransson*1, Mikael Benson2, Jonas S Erjefält3, Lennart Jansson4, Rolf Uddman1, Sven Björnsson5, Lars-Olaf Cardell1 and Mikael Adner1 Address: 1Laboratory of Clinical and Experimental Allergy Research, Department of Oto-Rhino-Laryngology, Malmö University Hospital, Lund University, Malmö, Sweden, 2Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden, 3Department of Experimental Medical Science, Lund University Hospital, Lund University, Sweden, 4AstraZeneca R&D, Lund, Sweden and 5Department of Clinical Chemistry, Malmö University Hospital, Lund University, Malmö, Sweden Email: Mattias Fransson* - [email protected]; Mikael Benson - [email protected]; Jonas S Erjefält - [email protected]; Lennart Jansson - [email protected]; Rolf Uddman - [email protected]; Sven Björnsson - [email protected]; Lars-Olaf Cardell - [email protected]; Mikael Adner - [email protected] * Corresponding author Abstract Background: Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood. Toll-like receptor 9 (TLR9) is a receptor for unmethylated CpG dinucleotides found in bacterial and viral DNA. The present study was designed to examine the expression of TLR9 in the nasal mucosa and in leukocytes derived from different cellular compartments during symptomatic allergic rhinitis. Methods: The study was based on 32 patients with seasonal allergic rhinitis and 18 healthy subjects, serving as controls. Nasal biopsies were obtained before and after allergen challenge. Bone marrow, peripheral blood and nasal lavage fluid were sampled outside and during pollen season. The expression of TLR9 in tissues and c

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