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Cultured bovine aortic endothelial cells show increased histamine metabolism when exposed to oscillatory shear stress

Authors
Journal
Atherosclerosis
0021-9150
Publisher
Elsevier
Publication Date
Volume
64
Issue
1
Identifiers
DOI: 10.1016/0021-9150(87)90054-2
Keywords
  • Bovine Aortic Endothelial Cells
  • Histamine
  • Histidine Decarboxylase
  • Shear Stress

Abstract

Abstract Oscillatory shear stress applied to the lining of blood vessels causes endothelial cell injury, one of the essential postulated prerequisites to the development of atherosclerosis. The purpose of this investigation was to study effects of shear stress on bovine aortic endothelial cells (BAEC), in vitro, for varying lengths of time (6 h, 12 h, 24 h) on BAEC histamine content (HC) and histidine decarboxylase activity (HD). Low intensity stress (1.6 dynes/cm 2) as well as intermediate and high intensity shear stresses (3.5 dynes/cm 2 and 7.6 dynes/cm 2) resulted in an accelerated HD (281%) and elevated HC (144%). These data indicate that oscillatory shear stress produces increases in histamine metabolism.

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