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FAD-linked glycerophosphate dehydrogenase deficiency in pancreatic islets of mice with hereditary diabetes

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
316
Issue
3
Identifiers
DOI: 10.1016/0014-5793(93)81297-d
Keywords
  • Pancreatic Islet
  • Fad-Linked Glycerophosphate Dehydrogenase
  • Db/Dbmouse
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase plays a key role in the glucose-sensing device of the insulin-producing pancreatic B-cell. Its activity was found to be decreased in islet, but not liver, homogenates of BL/Ks- db/db mice, in which diabetes mellitus represents an inherited disease. The decreased activity of FAD-linked glycerophosphate dehydrogenase contrasted with a normal activity of glutamate dehydrogenase and 2-ketoglutarate dehydrogenase in the islets of db/db mice. It is proposed that a site-specific defect of FAD-linked glycerophosphate dehydrogenase in the pancreatic B-cell might represent a far-from-uncommon causal or contributing factor in the pathogenesis of non-insulin-dependent diabetes mellitus.

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