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The effect of aflatoxin B1on the maturation of ribosomal and transfer RNA in monkey kidney (CV-1) cells in culture

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
9
Issue
6
Identifiers
DOI: 10.1016/0009-2797(74)90024-6

Abstract

Abstract Aflatoxin B 1 has been found to inhibit the maturation of rRNA by causing a build-up of 32S RNA in the nucleolus associated with reduced output of 28S rRNA to the cytoplasm. Processing of 18S rRNA appears normal. Other experiments on the maturation of tRNA have shown that again aflatoxin B 1 delays the processing of the precursor. The mechanism of action of the toxin and the relationship between these results and the observed inhibition of transcription are discussed.

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