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Chronic morphine exposure blocks opioid effects on both the early and late inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
110
Issue
3
Identifiers
DOI: 10.1016/0304-3940(90)90872-7
Keywords
  • Opiate Tolerance
  • Withdrawal
  • μ-Opioid Receptor
  • Hippocampal Slice Preparation
  • Inhibitory Postsynaptic Potential

Abstract

Abstract The μ-opioid agonist, [ N- MePhe 3, d-Pro 4] morphiceptin (PL017), significantly decreased the conductance changes measured during both the early and late inhibitory postsynaptic potentials (IPSP) in CA1 pyramidal cells. Although the conductance change during the early IPSP was much larger than that during the late IPSP, the relative decrease in conductance caused by 1 μM PL017 was similar for both. Chronic morphine treatment of rats prior to hippocampal slice preparation resulted in a loss of PL017 (1 μM) effects on both the early and late IPSPs. These results suggest that opioids have an equal ability to alter both early and late IPSPs in the CA1, that these effects are equally sensitive to chronic morphine, and that these measurements are a sensitive means of determining opioid tolerance in the hippocampus.

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