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The extent of late gadolinium enhancement can be assessed fast and reproducible using semi-quantitative method in patients with hypertrophic cardiomyopathy

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Identifiers
DOI: 10.1186/1532-429x-15-s1-e118
Keywords
  • Poster Presentation

Abstract

The extent of late gadolinium enhancement can be assessed fast and reproducible using semi-quantitative method in patients with hypertrophic cardiomyopathy POSTER PRESENTATION Open Access The extent of late gadolinium enhancement can be assessed fast and reproducible using semi- quantitative method in patients with hypertrophic cardiomyopathy Frank Gommans1*, Jeannette Bakker3, Etienne Cramer1, Maurice J Kurvers2, Freek W Verheugt1, Marc A Brouwer1, Marcel Kofflard2 From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013 Background In hypertrophic cardiomyopathy (HCM) assessment of late gadolinium enhancement (LGE) is increasingly important as LGE has been demonstrated to be an adverse prognosticator. Manual delineation of LGE after visual assessment is labour-intensive. Automatic quanti- fication is limited by its dependence on signal/noise ratio and varying definition of LGE. Our aim is to assess inter-individual agreement of a fast semi-quantitative method based on visual assessment for quantification of LGE in HCM, which is feasible for daily clinical practice. Methods We included 88 patients (60 clinical HCM patients, 28 subclinical HCM mutation carriers); age 48.9±15.0 years; 42 males. MRI was performed with 3D-contrast- enhanced inversion recovery imaging. Each segment of the AHA-17-segment model was scored to determine extent of LGE (0=no LGE, 1=1-25%, 2=26-50%, 3=51- 75%, 4=76-100%) by two independent observers. The score was summed and converted to a percentage of the maximum possible score (68) to estimate the extent of LGE relative to LV mass. LGE results were compared to assess inter-individual agreement on the presence and extent of LGE in all subjects and in subjects that were LGE positive according to both observers, respectively. Results The agreement on the presence and the extent of LGE was good (kappa=0.768 and r=0.861, p<0.001, respec- tively). Regarding presence of LGE: in 10 of 88 patients (11%) there was disagreem

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