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A simple and efficient method of preparing α-bromo carboxylic acids

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
39
Issue
52
Identifiers
DOI: 10.1016/s0040-4039(98)02204-7

Abstract

Abstract A new and convenient method for α-bromination of aliphatic carboxylic acids is reported. Heating carboxylic acids for 16 hours at 85 °C in trifluoroacetic acid with 1.5 equivalents of N-bromosuccinimide and a catalytic amount of concentrated H 2SO 4 leads to good yields of the respective α-bromocarboxylic acids.

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