Affordable Access

Publisher Website

Chronic Myeloid Leukemia with a Rare Variant Philadelphia Translocation:t(9;22;21)(q34;q11;q22)

Authors
Journal
Cancer Genetics and Cytogenetics
0165-4608
Publisher
Elsevier
Publication Date
Volume
116
Issue
2
Identifiers
DOI: 10.1016/s0165-4608(99)00115-6

Abstract

Abstract A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the first time, this translocation has been characterized by fluorescence in situ hybridization (FISH) and the reverse transcriptase polymerase chain reaction (RT-PCR). FISH, with the use of whole-chromosome painting probes and probes specific for the BCR and ABL genes, showed a three-way variant Philadelphia translocation (9;22;21)(q34;q11;q22) with a BCR/ABL fusion residing on the der(22). In addition, RT-PCR demonstrated a b2a3 BCR/ABL fusion transcript. Underlying mechanisms and prognostic implications are discussed.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Chronic myeloid leukemia with a rare variant Phila...

on Cancer Genetics and Cytogeneti... Jan 15, 2000

Chronic myeloid leukemia with a rare variant BCR-A...

on Cancer Genetics and Cytogeneti... November 2007

Chronic myeloid leukemia with a rare variant Phila...

on Cancer Genetics and Cytogeneti... Jan 01, 2001

Chronic myeloid leukemia with a rare variant Phila...

on Cancer Genetics and Cytogeneti... August 2001
More articles like this..