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Effects of chronic diphenylhydantoin on cerebral metabolism in the adult rat

Authors
Journal
Experimental Neurology
0014-4886
Publisher
Elsevier
Publication Date
Volume
99
Issue
3
Identifiers
DOI: 10.1016/0014-4886(88)90169-0

Abstract

Abstract Diphenylhydantoin is one of the most widely used anticonvulsant agents in humans. To examine its effects on brain metabolism, we used the quantitative autoradiographic [ 14C]deoxyglucose method to measure local cerebral glucose utilization in adult rats receiving 50 mg/kg/day diphenylhydantoin for 1 week. Thirty-three brain structures were analyzed to determine whether the drug has global or site-specific effects on cerebral metabolism. Chronic administration produced statistically significant decreases in 23 neocortical and subcortical structures compared with those in vehicle-injected control animals. Therefore, our data support the concept that diphenylhydantoin has widespread depressant effects on brain metabolism.

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