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A new synthesis of deglyco-bleomycin A2 aiming at the total synthesis of bleomycin

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
23
Issue
5
Identifiers
DOI: 10.1016/s0040-4039(00)86880-x

Abstract

Abstract An improved route to synthesize deglyco-bleomycin A2, the aglycon of bleomycin A2, aiming at the total synthesis of bleomycin is described. The new route is characterized by the stepwise elongation of the amino acid constituents and the use of a thiol ester obtained by aldol condensation.

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