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Antigen-induced suppressor T cells from the skin point of view:Suppressor T cells induced through epicutaneous immunization

Authors
Journal
Journal of Neuroimmunology
0165-5728
Publisher
Elsevier
Publication Date
Volume
167
Identifiers
DOI: 10.1016/j.jneuroim.2005.06.004
Keywords
  • Tolerance
  • Suppressor T Cells
  • Autoimmunity
  • Epicutaneous Immunization
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The rebirth of interest in suppressor T cells has spawned a vast amount of data that shed light on their biology and role in immune system homeostasis. Since the early studies on the naturally occurring CD4+ / CD25+ T regulatory cells, much attention has been focused on ways to induce suppressor T cells in vivo. This review discusses the salient features of the induction of antigen-specific suppressor T cells in a T cell receptor (TCR) transgenic mouse model of experimental allergic encephalomyelitis (EAE) in response to epicutaneous immunization with cognate peptide. We discuss the skin environment as a privileged anatomical site for therapeutic intervention against pro-inflammatory auto-immune disorders using non-invasive approaches for antigen delivery.

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