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Straightforward synthesis of enantiopure 2-aminomethyl and 2-hydroxymethyl pyrrolidines with complete stereocontrol

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
46
Issue
8
Identifiers
DOI: 10.1016/j.tetlet.2004.12.119

Abstract

Graphical abstract A practical synthesis of 2-aminomethyl- and 2-hydroxymethyl-3,4-dihydroxypyrrolidines via stereocontrolled addition of TMSCN and LiCH 2OMOM to chiral 3,4 dihydro-2 H-pyrroline N-oxides is reported.

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