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Designing of the Mucoadhesive Intravaginal Spermicidal Films

Authors
Journal
Indian Journal of Pharmaceutical Sciences
0250-474X
Publisher
OMICS Publishing Group
Publication Date
Volume
72
Issue
5
Identifiers
DOI: 10.4103/0250-474x.78540
Keywords
  • Short Communication
Disciplines
  • Chemistry

Abstract

A mucoadhesive drug delivery system for local delivery of metronidazole through vaginal route was formulated. Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol. The films were evaluated for their weight, thickness, surface pH, folding endurance, mechanical, drug content uniformity, in vitro drug release, swelling, gelling and mucoadhesion property. All the films possess satisfactory film characteristics. Films made of Polyox found to possess acceptable, physicochemical, mechanical, gelling and mucoadhesion property for delivery of metronidazole.

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