Affordable Access

Publisher Website

The importance of urinary protein excretion during conservative management of severe preeclampsia

American Journal of Obstetrics and Gynecology
Publication Date
DOI: 10.1016/s0002-9378(96)70047-9
  • Preeclampsia
  • Proteinuria
  • Conservative Management
  • Biology
  • Medicine


Abstract OBJECTIVES: We determined the natural course of urinary protein excretion during conservative management of severe preeclampsia and investigated whether changes in urinary protein excretion can predict maternal or perinatal outcome. STUDY DESIGN: We reviewed the medical charts of 66 women with severe preeclampsia which was managed conservatively before 32 weeks of gestation and who had at least two 24-hour urinary protein determinations 4 or more days apart after admission. RESULTS: Fifty-nine (89%) of 66 women had an increase in proteinuria during conservative management of severe preeclampsia. The median increase in protein excretion after admission was 660 mg/24 hours (range -4580 to 18,960 mg/24 hours). Patients were divided into two groups. The first group ( n = 24) had an increase in 24-hour urinary protein excretion of ≥2 gm; the second group ( n = 42) had a 24-hour urinary protein excretion that decreased ( n = 7) or increased by <2 gm ( n = 35). There were no cases of eclampsia or stillbirth in either group. The rate of HELLP (hemolysis, elevated liver enzyme levels, low platelet counts) syndrome, abruptio placentae, cesarean delivery because of fetal distress, 5-minute Apgar scores ≤6, and the admission-to-delivery intervals were all similar in the two groups. CONCLUSIONS: Proteinuria increases in most women with severe preeclampsia managed conservatively. No differences in maternal or fetal outcomes were found between pregnancies with marked increases in proteinuria and those with modest or no increases. (Am J Obstet Gynecol 1996;175:1313-6.)

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

The importance of urinary protein excretion during...

on American Journal of Obstetrics... November 1996

Urinary calcium excretion in severe preeclampsia a...

on Clinical chemistry and laborat... 2006

In defense of the conservative management of sever...

on American Journal of Obstetrics... Dec 15, 1985

Urinary protein excretion and expectant management...

on International Journal of Gynec... Jan 01, 2002
More articles like this..