Affordable Access

Publisher Website

Cellular and Molecular Effects of Thymic Epithelial Cells on Thymocytes during Differentiation and Maturation

Elsevier Science & Technology
DOI: 10.1016/s0074-7696(08)62254-8
  • Medicine


Publisher Summary This chapter reviews: (1) the cellular and molecular relationship between thymocytes and thymic epithelial cells (TECs), (2) partial purification of THPs from TEC culture supernatant, (3) the parameters reflecting thymocyte differentiation and maturation, (4) the thymocyte subset which is sensitive for each THP, and (5) regulation of TEC function from a viewpoint of endocrine organs and the autonomic nervous system. It is shown that thymic epithelial cells release thymus hormonal products which participate in T-cell production by affecting the proliferation, differentiation, and maturation of thymocytes. Several hormones from endocrine organs and neurotransmitters from the autonomic nervous system innervated into thymic parenchyma appear to regulate the function of thymic epithelial cells. The new information presented in the chapter clearly indicates that there is neuro-endocrine-immunological coordination in the thymic microenvironment.

There are no comments yet on this publication. Be the first to share your thoughts.