Abstract Tests on Yinzhuang Sandstone for measuring permeability under different confining pressure, pore pressure and specimen dimensions were carried out with an orthogonal experimental design Table L16(43), having 3 experimental factors and 4 levels. A total of 16 tests had been performed. The permeability of Yinzhuang sandstone was found as a function of the axial stress and strain strongly. But the effect of confining pressure, pore pressure and specimen dimensions on permeability was not obvious for most regions in a complete stress-strain path. Only in some individual regions, some individual factors discovered its own significant effect. For example, the confining pressure gave most significant influence on permeability in the strain-softening region, whereas the ratio of pore pressure to confining pressure discovered an obvious effect only on the value of highest permeability.