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A novel lanosterol isomer produced in response to azole antifungals

Authors
Journal
Journal of Steroid Biochemistry
0022-4731
Publisher
Elsevier
Publication Date
Volume
36
Issue
5
Identifiers
DOI: 10.1016/0022-4731(90)90095-a

Abstract

Abstract Gas chromatography-mass spectrometry has revealed the existence of a novel lanosterol-like sterol which is produced by fungi in response to treatment with azole drugs. The significance of this finding may be related to the changes in fungal sterol synthesis as a consequence to prolonged exposure to azoles and consequent development of resistance to these agents.

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