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Electron microscope studies in experimental thrombosis

Authors
Journal
Experimental and Molecular Pathology
0014-4800
Publisher
Elsevier
Publication Date
Volume
1
Issue
6
Identifiers
DOI: 10.1016/0014-4800(62)90042-4

Abstract

Abstract Thrombi were produced experimentally in rats and studied at various stages of organization with the electron microscope. Fibrin, which is a prominent constituent of the early thrombus, was virtually absent after 4 days. There was evidence of collagen formation within the wall at 2 days, and there was extensive fibrogenesis within the thrombus at 4 days. The thrombi were first recanalized by solid cell cylinders which were converted into mature capillaries by a process of growth and fusion of extracellular spaces between adjacent endothelial cells. Other significant features and problems relating to the organization of thrombi are briefly discussed.

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