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The widely used anesthetic agent propofol can replace α-tocopherol as an antioxidant

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
357
Issue
1
Identifiers
DOI: 10.1016/0014-5793(94)01337-z
Keywords
  • Lipid Peroxidation
  • α-Tocopherol
  • Glutathione
  • Propofol
  • Antioxidant
Disciplines
  • Chemistry

Abstract

Abstract The cell membrane is protected against lipid peroxidation through endogenous antioxidants such as the lipid soluble α-tocopherol. The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to α-tocopherol, since it also contains a phenolic OH-group. The transient protection of GSH against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in α-tocopherol. Introducing propofol (2 and 5 μM) restored the protective effect of GSH. Similar to the control microsomes the GSH-protective effect did not occur in previously heated microsomes. These results suggest that propofol acts similarly to α-tocopherol as a chain breaking antioxidant in liver microsomal membranes.

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