Affordable Access

Publisher Website

Interleukin 1β improves survival following cecal ligation and puncture

Authors
Journal
Journal of Surgical Research
0022-4804
Publisher
Elsevier
Publication Date
Volume
52
Issue
5
Identifiers
DOI: 10.1016/0022-4804(92)90321-p
Disciplines
  • Medicine

Abstract

Abstract Despite antibiotic therapy intra-abdominal sepsis following major surgery is a significant cause of mortality. We sought to determine if interleukin-1β (IL-1) could improve survival in a murine model of intra-abdominal infection. Groups of 10 BDF 1 mice received a single subcutaneous (sc) injection of recombinant human IL-1β 24 hr prior to cecal ligation and puncture (CLP) and were assessed twice daily for survival. Mice that received a single injection of IL-1β 24 hr prior to CLP had a dose-dependent improval in survival compared to controls. The beneficial effect of IL-1 treatment may have been related to its ability to stimulate myelopiesis. The addition of indomethacin, in an effort to limit possible toxicity of IL-1, did not further improve survival. Appropriate timing of specific immunomodulators may provide an additional strategy for the treatment of infections.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Interleukin 1 beta improves survival following cec...

on Journal of Surgical Research May 1992

Adenosine A1 receptor antagonist, L-97-1, improves...

on European Journal of Pharmacolo...

Adenosine A1 receptor antagonist, L-97-1, improves...

on European Journal of Pharmacolo... Oct 05, 2014

Role of hypothalamic interleukin-1beta in fever in...

on The American journal of physio... September 1998
More articles like this..