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ISCHÆMIC HEART-DISEASE: POSSIBLE GENETIC MARKERS

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
306
Issue
7937
Identifiers
DOI: 10.1016/s0140-6736(75)90777-1
Disciplines
  • Medicine

Abstract

Abstract National death-rates from ischæmic heart-disease are significantly correlated with population frequencies of histocompatibility antigen HLA-8 and haplotype 1-8. Serum-cholesterol levels may also be correlated with population frequencies of HLA-8. Inexplicably high death-rates from ischæmic heart-disease and high levels of serum-cholesterol in Finland may be due to the combined effects of HLA-8 and W15. It is suggested that HLA-8 (and possibly W15) are linked to genes which predispose to hypercholesterolæmia and ischæmic heart-disease. These findings provide some support for immunogenetic hypotheses for vascular disease in man.

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