Affordable Access

Publisher Website

Substance P found to lower body temperature and aggression

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
86
Issue
3
Identifiers
DOI: 10.1016/0006-291x(79)91788-1

Abstract

Abstract Synthetic substance P (SP) was bioassayed in mice by a procedure comprising eleven subtests. Two replications of a dose-response study were conducted at the time of the peak effect of the intravenous injection of SP. Single doses of 31 and 63 ng/kg significantly decreased body temperature. SP, [D-Arg 1]-SP, and [des-NH 2-Arg 1]-SP comparably lowered blood pressure, but [D-Arg 1]-SP and [des-NH 2-Arg 1]-SP were 1 20 to 1 10 as active as SP in lowering body temperature. The activities that lower body temperature and blood pressure may be different. The thyrotropin and luteinizing hormone releasing hormones (TRH and LH-RH) did not lower body temperature. SP also decreased the aggressive response (ED 50, 89 ng/kg).

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Substance P found to lower body temperature and ag...

on Biochemical and Biophysical Re... Feb 14, 1979

Aggression, body temperature, and stress ulcer

on Physiology & Behavior Jan 01, 1984

Aggression, body temperature, and stress ulcer.

on Physiology & Behavior February 1984

Maximal body temperatures found in health.

on Annals of western medicine and... April 1947
More articles like this..