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Copper-catalyzed N-arylation of sulfonamides with aryl bromides under mild conditions

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
53
Issue
1
Identifiers
DOI: 10.1016/j.tetlet.2011.10.113
Keywords
  • Sulfonamide Coupling
  • Copper Catalysis
  • N-Arylation

Abstract

Abstract This Letter describes a copper catalyzed sulfonamide coupling reaction with aryl bromides to form N-aryl sulfonamides under mild conditions, including the first examples of Cu-catalyzed sulfonamide coupling at room temperature. The reaction protocol tolerates a broad range of substrates including a variety of primary and secondary sulfonamides and challenging heteroaryl bromides such as 2-bromothiazole.

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