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Imaging manifestations of progressive multifocal leukoencephalopathy

Authors
Journal
Clinical Radiology
0009-9260
Publisher
Elsevier
Publication Date
Volume
65
Issue
6
Identifiers
DOI: 10.1016/j.crad.2010.03.001
Disciplines
  • Medicine
  • Physics

Abstract

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of JC virus in immunosuppressed patients. The diagnosis is usually suggested on imaging and confirmed by cerebrospinal fluid polymerase chain reaction (PCR) for JC virus DNA. In this article, we review the imaging manifestations of PML on computed tomography (CT), magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), MR spectroscopy, single photon-emission computed tomography (SPECT) and positron-emission tomography (PET), and outline the role of imaging in follow-up and prognostication.

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