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The impact of lymph node disease in extremity soft-tissue sarcomas: a population-based analysis

Authors
Journal
The American Journal of Surgery
0002-9610
Publisher
Elsevier
Volume
206
Issue
3
Identifiers
DOI: 10.1016/j.amjsurg.2012.10.043
Keywords
  • Lymph Node
  • Sarcoma
  • Extremity
  • Prognosis
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Background Because of the low incidence of regional lymph node metastasis, node-positive soft-tissue sarcoma patients remain poorly characterized. Our objective was to assess regional lymph node metastasis in extremity sarcoma patients using a large population database. Methods The Surveillance, Epidemiology, and End Results database was queried for extremity sarcoma patients. Clinicopathologic data and outcomes were examined to evaluate the significance of regional lymph node metastasis. Results Of 7,159 patients without distant metastasis, 64 patients had identified regional lymph node metastasis (.9%). Regional lymph node metastasis was associated with younger age, tumor grade, size, invasion, and tumor subtype. Excluding distant metastasis, lymph node status was the strongest prognostic factor (hazards ratio = 5.1, P < .001). Conclusions Isolated regional lymph node metastasis is rare in extremity sarcoma patients. However, in the absence of distant metastasis, lymph node status is the most important prognostic factor. The management of positive lymph nodes remains uncertain although diagnosing lymph node metastasis may identify early biologically aggressive disease.

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