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Angiopoietin-like 4 (Angptl4) : A glucocorticoid-dependent gatekeeper of fatty acid flux during fasting

Authors
Journal
Adipocyte
2162-3945
Publisher
Landes Bioscience
Publication Date
Volume
1
Issue
3
Identifiers
DOI: 10.4161/adip.20787
Keywords
  • Commentary
Disciplines
  • Biology
  • Medicine

Abstract

Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting. In investigating the role of Angptl4 in glucocorticoid action, we identified that in addition to its known ability to inhibit lipoprotein lipase, Angptl4 stimulates intracellular adipocyte lipolysis. Fatty acid release by murine adipocytes following fasting or treatment with glucocorticoids or catecholamines is highly Angptl4-dependent. In fact, Angptl4 can directly stimulate cAMP-dependent PKA signaling and lipolysis when added to adipocytes. Here, we detail this novel Angptl4-dependent lipolytic regulatory mechanism and discuss its physiological and therapeutic implications.

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