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Physicochemical and release properties of pellets coated with Kollicoat®SR 30 D, a new aqueous polyvinyl acetate dispersion for extended release

International Journal of Pharmaceutics
Publication Date
DOI: 10.1016/j.ijpharm.2004.10.024
  • Aqueous Colloidal Polymer Dispersions
  • Curing
  • Extended Release
  • Kollicoat®Sr 30 D
  • Pellets


Abstract Kollicoat ® SR 30 D is a new aqueous colloidal polyvinyl acetate dispersion used for extended release coatings. Kollicoat ® SR 30 D is stable against sedimentation, has a low viscosity (54 mPas) and a negative zeta potential of −23.2 mV because of the presence of the anionic surfactant, sodium dodecyl sulfate. Because of its low minimum film formation temperature (MFT = 18 °C), plasticizer addition and a thermal after-treatment (curing) of coated pellets was not required. Coated pellets showed no aging or curing effect. The rate of release could be easily adjusted by varying the coating level. A subcoating layer of the hydrophilic polymer, polyvinyl alcohol, between an ibuprofen-containing core and the Kollicoat ® SR coating prevented the diffusion of the lipophilic, low melting ibuprofen into the polymer coating during storage. The drug release from Kollicoat ® SR 30 D coated pellets was almost independent of the pH and ionic strength of release medium.

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