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Baseline compensation for gradient elution high-performance liquid chromatography with a dynamically referenced flow cell

Authors
Journal
Analytica Chimica Acta
0003-2670
Publisher
Elsevier
Publication Date
Volume
157
Identifiers
DOI: 10.1016/s0003-2670(00)83639-9

Abstract

Abstract Stable baselines were obtained with a gradient test system of acetone in methanol by using a secondary pump circuit at atmospheric pressure to simulate the gradient formed by the primary (high pressure) circuit. The secondary gradient system is used dynamically to reference the flow cell, thus eliminating baseline drift when detector-active mobile phases are used in gradient elution.

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