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Effects of prostaglandin D2on helper T cell functions

Elsevier Inc.
Publication Date
DOI: 10.1016/j.bbrc.2004.02.151


Abstract Prostaglandin (PG) D 2 is abundantly produced by mast cells in the sites of allergic inflammations and acts on various cell types through its receptors DP and CRTH2. Among human T cells, CRTH2 is preferentially expressed on Th2-type cells. However, distribution of DP among T cells and impacts of CRTH2- and DP-mediated signals on T cell functions are presently unclear. Here, we show that CD4 + and CD8 + T cells producing IFN-γ and IL-2 were reduced by DP-mediated signals, while CRTH2-mediated signals enhanced IL-2, IL-4, IL-5, and IL-13 production by Th2 cells. CRTH2 signals also caused up-regulation of CD11b and CD40L in resting Th2 cells. RT-PCR analysis revealed distribution of DP among Th cell subsets. On CRTH2 + Th2 cells, the CRTH2-mediated PGD 2 effects were dominantly observed. Thus, PGD 2 favors Th2 functions through CRTH2 while restraining Th1 functions via DP, which may contribute to development of Th2-dominated status in allergic inflammations.

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