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Induction of early decidualization by cadmium, a major contaminant of cigarette smoke

Authors
Journal
Fertility and Sterility
0015-0282
Publisher
Elsevier
Publication Date
Volume
91
Issue
4
Identifiers
DOI: 10.1016/j.fertnstert.2008.12.055
Keywords
  • Cadmium
  • Decidualization
  • Prolactin
  • Igfbp-1

Abstract

To investigate the effect of cadmium (Cd) contamination on endometrial function, human endometrial stromal cells were isolated and cultured with E 2 plus P in the presence of Cd, a major contaminant in cigarette smoke, and assayed for PRL concentrations and its messenger RNA expression. Cd significantly increased PRL concentrations in the culture media and significantly up-regulated PRL messenger RNA expression of the endometrial stromal cells, suggesting that Cd stimulates decidualization of the endometrium and may disrupt endometrial environment, causing early decidualization.

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