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Uncoupling of oxidative leak formation from lipid peroxidation in the human erythrocyte membrane by antioxidants and desferrioxamine

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Biomembranes
0005-2736
Publisher
Elsevier
Publication Date
Volume
899
Issue
1
Identifiers
DOI: 10.1016/0005-2736(87)90246-x
Keywords
  • T-Butylhydroperoxide
  • Antioxidant
  • Lipid Peroxidation
  • Membrane Leak Permeability
  • Desferrioxamine
  • (Erythrocyte)
Disciplines
  • Biology

Abstract

Abstract Human erythrocytes, briefly exposed to t-butylhydroperoxide and then incubated further in the absence of exogenous oxidant, undergo lipid peroxidation and formation of aqueous membrane leaks. Leak formation can be suppressed by various types of antioxidants and by desferrioxamine at concentrations at which lipid peroxidation still proceeds almost unaltered. This uncoupling of the two manifestations of an oxidative membrane damage indicates that loss of the barrier properties is not an obligatory consequence of the presence of peroxidized lipids in biological membranes.

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