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Potentiation by the human liver fluke, Opisthorchis viverrini, of the carcinogenic action of N-nitrosodimethylamine upon the biliary epithelium of the hamster.

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Research Article
  • Biology
  • Chemistry
  • Medicine


Br. J. Cancer (1982) 46, 985 Short Communication POTENTIATION BY THE HUMAN LIVER FLUKE, OPISTHORCHIS VIVERRINI, OF THE CARCINOGENIC ACTION OF N-NITROSODIMETHYLAMINE UPON THE BILIARY EPITHELIUM OF THE HAMSTER D. J. FLAVELL AND S. B. LUCAS* From the Department of Medical Heminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans, Herts AL4 OXQ and *Department of Histopathology, St Thomas' Hospital, London SE1 7EH Receive( 5 July 1982 A CAUSAL RELATIONSHIP between infec- tion with the liver fluke, Opisthorchis viverrini, and intrahepatic bile-duct car- cinoma (cholangiocarcinoma) in man is strongly suspected (Sonakul et al., 1978; Flavell, 1981) though not yet conclusively proven. The liver pathology of opisthor- chiasis has been adequately described in man (Tansurat, 1971) and well studied in the hamster (Bhamarapravati et al., 1978; Flavell et al., 1980b), though in our experience life-time infections in golden Syrian hamsters do not result in the production of bile-duct tumours. The hypothesis has been presented that liver-fluke infection of man renders the biliary epithelium more susceptible to malignant transformation by chemical or other exogenous carcinogenic stimuli (Flavell, 1981; Gibson & Chan, 1972; Thamavit et al., 1978). In the study described here we chose to investigate the influence of an experimental 0. viverrini infection in Golden Syrian hamsters on the pattern of appearance of primary liver tumours following a single treatment with the carcinogen N-nitrosodimethylamine (DMN) at a dose normally ineffective at inducing bile-duct cancer in this animal species. Three groups of Golden Syrian hamsters were treated as follows: Group 1. 50 0. viverrini metacercariae + 1 6 mg. DMN (50 animals) Accepted 3 September 1982 Group 2. 1-6 mg.DMN only (30 animals) Group 3. 50 0. viverrini metacercariae only (50 animals) Metacercariae obtained from naturally- infected Cyprinoid fish were administered to animals intrag

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