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Effect of dosage form, food, and an anticholinergic drug on the bioavailability of sulphide

Authors
Journal
International Journal of Pharmaceutics
0378-5173
Publisher
Elsevier
Publication Date
Volume
37
Issue
3
Identifiers
DOI: 10.1016/0378-5173(87)90033-0
Keywords
  • Sulpiride
  • Bioavailability
  • Formulation Influence On Bioavailability
  • Sulpiride-Food Interaction
  • Sulpiride-Propantheline Interaction

Abstract

Abstract The oral bioavailability of 3 different dosage forms of sulpiride (Dogmatil), as measured by total 48-h urinary excretion, was studied in 6 healthy male volunteers. Administration of 200 mg of the drug as capsules, tablets and syrup resulted in mean absorptions of 31%, 26% and 20%, respectively. The bioavailability from the syrup was significantly less (ANOVA, P < 0.05) than that from capsules. Coadministration of food or an anticholinergic drug, propantheline bromide, with the syrup increased the mean bioavailbility of the drug to about 26%. The results suggest that the delay in gastric emptying and intestinal transit time due to food or propantheline bromide allows for a better site-specific absorption of sulpiride from the intestine.

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