Affordable Access

Publisher Website

Genotoxic activity of caramel on Salmonella and cultured mammalian cells

Authors
Journal
Mutation Research Letters
0165-7992
Publisher
Elsevier
Publication Date
Volume
139
Issue
4
Identifiers
DOI: 10.1016/0165-7992(84)90121-0

Abstract

Abstract The genetic activity of 2 commercial caramel preparations, manufactured either by heating the malt sugar solution directly (non-ammoniated caramel) or by heating it with ammonia (ammoniated caramel) was studied in the Salmonella mutagenicity test and UDS assay in cultured mammalian cells. The non-ammoniated caramel was found to be mutagenic to S. typhimurium TA100, while the ammoniated one was genetically active in all the tester strains used, namely TA100, TA97 and TA98. It was also demonstrated that non-ammoniated caramel was capable of inducing UDS in cultured human amnion FL cells, but for the ammoniated one, no such activity was observed. Furthermore, based on the results obtained in the DNA synthesis inhibition assay, it was suggested that the DNA synthesis inhibition seen in our experiments with the ammoniated caramel was probably not of DNA damage in origin. These data indicate that the mutagenic fractions formed during ammoniated and non-ammoniated caramelization were quite different.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Genotoxic activity of caramel on Salmonella and cu...

on Mutation Research/Fundamental... April 1984

Cytotoxic and Genotoxic Activity of 1,3-Dichloropr...

on Toxicology and Applied Pharmac... Jan 01, 1993

Cytotoxic and genotoxic activity of 1,3-dichloropr...

on Toxicology and Applied Pharmac... May 1993

Comparative genotoxic effects of IQ and MeIQ in Sa...

on Mutation Research/Fundamental... April 1987
More articles like this..