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Vertical and horizontal integrator failure in a ponto-medullary infarction: A possible role for paramedian tract neurons

Authors
Journal
Journal of the Neurological Sciences
0022-510X
Publisher
Elsevier
Publication Date
Volume
280
Identifiers
DOI: 10.1016/j.jns.2009.02.356
Keywords
  • Gaze-Evoked Nystagmus
  • Neural Integrator
  • Paramedian Tract Neurons
  • Neuroophthalmology

Abstract

Abstract Gaze-evoked nystagmus is caused by a “leaky” neural integrator, which fails to maintain eccentric gaze positions after centrifugal eye movements. It is usually observed as the result of toxic, metabolic or paraneoplastic disorders, rather than single structural lesions. We demonstrate a case of an omnidirectional gaze-evoked nystagmus due to an ischemic paramedian ponto-medullar infarction. The most probable explanation is a damage of paramedian tract neurons, which have been recently recognized as a site of neural integration.

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