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Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
49
Issue
5
Identifiers
DOI: 10.1016/j.phrs.2003.12.006
Keywords
  • Meal Pattern
  • Enteric Coating
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Oleoylethanolamide (OEA) is an endogenous lipid that contributes in important ways to the peripheral regulation of food intake. When administered intraperitoneally, OEA is a potent satiety-inducing anorexiant in rats and mice [Nature 414 (2001) 209; Neuropsycopharmacology 28 (2003) 1311; Nature 425 (2003) 90]. In the present study, we show that oral administration of OEA in pH-sensitive enteric-coated capsules produces a profound and long-lasting inhibition of food intake in free-feeding rats. This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle.

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