Abstract 1. 1. Detoxification of sareophytoxide to deoxysarcophytoxide as suggested by Coll et al. (1983) was not observed in the egg cowrie, Ovula ovum, after voluntary ingestion of Sarcophyton species which contained sarcophytoxide. 2. 2. Nor was it observed in in vitro incubations of various sections of the Ovula ovum digestive tract, inclucling the digestive gland. 3. 3. Deoxysarcophytoxide was isolated from several sarcophytoxide containing Sarcophyton species and is concluded to be a biosynthetic precursor of sarcophytoxide.