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Aberrant splicing of rat steroid 17α-hydroxylase transcripts

Authors
Journal
Gene
0378-1119
Publisher
Elsevier
Publication Date
Volume
165
Issue
2
Identifiers
DOI: 10.1016/0378-1119(95)00536-f
Keywords
  • Exon Skipping
  • Polymerase Chain Reaction

Abstract

Abstract Polymerase chain reaction amplification of the cDNA encoding steroid 17α-hydroxylase (P450c17) demonstrated very low levels of this transcript and a shorter variant of still lower abundance in rat adrenals and brain. Sequence analysis of the two amplified products revealed that the shorter variant resulted from a deletion of the second exon which does not maintain the open reading frame, suggesting that faulty splicing gave rise to this minor species.

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