Affordable Access

Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole

Transplant Infectious Disease
Wiley Blackwell (Blackwell Publishing)
Publication Date
  • Medicine


We report a case of disseminated infection with Acanthamoeba in a patient with graft-versus-host disease after hematopoietic stem cell transplant (HSCT) for acute lymphocytic leukemia. The infection involved the brain, skin, and lungs and occurred despite treatment with voriconazole for mold prophylaxis, and did not respond to treatment with multiple other agents reported to have activity against Acanthamoeba . To our knowledge, infection with Acanthamoeba has been reported in 4 other patients after HSCT or bone marrow transplant, and our case is the first to be diagnosed ante-mortem.

There are no comments yet on this publication. Be the first to share your thoughts.